Alkylation of cycloalkano[ B ]indoles  via  indolylmagnesium salts: Synthesis of 3 h ‐indoles and oxidative rearrangement to spiro[cycloalkane‐1,2′‐indolin]‐3′‐ones | Zendy

Rodriguez JosÈGonzalo | Zendy; Andrès Angel San | Zendy

Premium

Alkylation of cycloalkano[ B ]indoles via indolylmagnesium salts: Synthesis of 3 h ‐indoles and oxidative rearrangement to spiro[cycloalkane‐1,2′‐indolin]‐3′‐ones

Author(s) -

Rodriguez JosÈGonzalo,

Andrès Angel San

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280522

Subject(s) - chemistry , cycloalkane , alkylation , methyl iodide , halide , alkyl , medicinal chemistry , selectivity , derivative (finance) , iodide , organic chemistry , catalysis , financial economics , economics

Alkylation of cycloalkano[ b ]indolylmagnesium iodide with alkyl halides has been analyzed to prepare cycloalkano‐3 H ‐indoles, methyl and N,N ‐dimethylpropyl derivatives. Spiro[cycloalkane‐1,2′‐indolin‐3′‐one] derivatives appear as secondary products in this reaction. Selectivity and optimization of the reaction has been determined and a mechanism for the formation of the spiro derivative is proposed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research