Premium
Carbamoylation of B 6 vitamins
Author(s) -
Ponticelli Fabio,
Marinello Enrico,
Pagani Roberto,
Terzuoli Lucia
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280512
Subject(s) - chemistry , cyanate , aldehyde , hydrochloric acid , adduct , vitamin b , group (periodic table) , organic chemistry , medicinal chemistry , vitamin , biochemistry , catalysis
The reaction of B 6 vitamins 1–3 with cyanate, in the presence of equivalent amounts of hydrochloric acid, yields different adducts according to the structure of the starting material. Regiospecific attack on the amino group or the phenolic hydroxy group was found for 2a,b and 3a,b , respectively. From the aldehydes 1a,b , the 2 H ‐pyrido[3,4‐ e ]‐1,3‐oxazin‐2‐ones 7a,b were obtained through an attack on both the phenolic and aldehyde group.