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Nitration products of substituted 1,3‐dihydro‐5‐phenyl‐2 H ‐1,4‐benzodiazepin‐2‐ones
Author(s) -
Fryer R. Ian,
Gu ZiQiang,
Todaro L.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280508
Subject(s) - nitration , chemistry , substituent , medicinal chemistry , crystal structure , single crystal , stereochemistry , organic chemistry , crystallography
Highly substituted, novel, 1,3‐dihydro‐5‐phenyl‐2 H ‐1,4‐benzodiazepin‐2‐ones were obtained by direct nitration of the corresponding mono‐ or di‐substituted 5‐phenyl‐1,4‐benzodiazepines. Substituent effects and the orientation of aromatic substituents in the nitration products are discussed. The single‐crystal X‐ray structural data for one of these products, 18 , is given.