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A novel approach to the pyrido[4,3‐ c ]pyridazine ring. Synthesis of pyrido[4,3‐ c ]pyridazin‐5(6 H )‐one from 3,4‐disubstituted pyridazines
Author(s) -
Vors JeanPierre
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280435
Subject(s) - chemistry , pyridazine , ring (chemistry) , ether , closure (psychology) , sequence (biology) , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , economics , market economy
The synthesis of new pyrido[4,3‐ c ]pyridazin‐5(6 H )‐one from ethyl 3‐methyl‐4‐pyridazinecarboxylate using an enamination/ring closure sequence is described. The starting material is easily available from a hetero Diels‐Alder reaction between a 1,2‐diaza‐1,3‐diene and ethyl vinyl ether and oxidation of the resulting 1,4,5,6‐tetrahydropyridazine.