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Synthesis of 5,6‐dihydro‐4 H ‐pyrrolo[1,2‐ a ]thieno[2,3‐ f ][1,4]diazepines
Author(s) -
Vega Salvador,
Gil M. Soledad
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280418
Subject(s) - chemistry , pyrrole , condensation , medicinal chemistry , aryl , combinatorial chemistry , reduction (mathematics) , stereochemistry , organic chemistry , alkyl , thermodynamics , physics , geometry , mathematics
The reduction of 1‐[3‐(thienyl‐2‐carbonitrile)]pyrrole, formed by condensation of 3‐aminothiophene‐2‐carbonitrile with 2,5‐dimethoxytetrahydrofuran, gave 1‐[3‐(thienyl‐2‐aminomethyl)]pyrrole. This compound was found to be a convenient intermediate for the preparation of 4‐aryl‐5,6‐dihydro‐4 H ‐pyrrolo[1,2‐ a ]thieno‐[2,3‐ f ][1,4]diazepines which was accomplished by two different synthetic routes.