Synthesis of 5,6‐dihydro‐4 H ‐pyrrolo[1,2‐ a ]thieno[2,3‐ f ][1,4]diazepines | Zendy

Vega Salvador | Zendy; Gil M. Soledad | Zendy

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Synthesis of 5,6‐dihydro‐4 H ‐pyrrolo[1,2‐ a ]thieno[2,3‐ f ][1,4]diazepines

Author(s) -

Vega Salvador,

Gil M. Soledad

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280418

Subject(s) - chemistry , pyrrole , condensation , medicinal chemistry , aryl , combinatorial chemistry , reduction (mathematics) , stereochemistry , organic chemistry , alkyl , thermodynamics , physics , geometry , mathematics

The reduction of 1‐[3‐(thienyl‐2‐carbonitrile)]pyrrole, formed by condensation of 3‐aminothiophene‐2‐carbonitrile with 2,5‐dimethoxytetrahydrofuran, gave 1‐[3‐(thienyl‐2‐aminomethyl)]pyrrole. This compound was found to be a convenient intermediate for the preparation of 4‐aryl‐5,6‐dihydro‐4 H ‐pyrrolo[1,2‐ a ]thieno‐[2,3‐ f ][1,4]diazepines which was accomplished by two different synthetic routes.

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