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A novel synthesis of 2‐arylaminothiazolo[4,5‐ d ]pyridazinones
Author(s) -
Yamasaki Tetsuo,
Kawaminami Eiji,
Uchimura Fumi,
Okawara Tadashi,
Furukawa Mitsuru
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280405
Subject(s) - chemistry , medicinal chemistry , stereochemistry
The reaction of 5(4)‐amino‐4(5)‐chloropyridazin‐3(2 H )‐ones 1 (9 ) with methyl dithiocarbamates 2 gave 2‐arylaminothiazolo[4,5‐ d ]pyridazinones 3 (10 ). Treatment of 5(4)‐alkylamino‐4(5)‐chloropyridazin‐3(2 H )‐ones 5 (12 ) with 2 afforded the corresponding 2‐aryliminothiazolo[4,5‐ d ]pyridazinones 6 (13 ). Cyclization of 1a with phenylisothiocyanate produced 2‐amino‐ and 2‐iminothiazolo[4,5‐ d ]pyridazinones 3a and 16 .
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