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The synthesis and chemistry of 5‐carboxy‐8‐mercaptoquinoline hydrochloride monohydrate: An intermediate in the synthesis of novel H + ,K + ‐ATPase inhibitors
Author(s) -
Zawistoski Michael P.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280321
Subject(s) - chemistry , yield (engineering) , pyrimidine , hydrochloride , sulfur , guanidine , chemical synthesis , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , materials science , metallurgy
The title compound 3 was prepared in six steps from 5‐nitro‐8‐hydroxyquinoline in 14% overall yield, using a substituted pyrimidine as a protecting group for sulfur. This offers a simple entry into the synthesis of 5‐carboxy‐8‐substituted thioquinolines, useful intermediates for the synthesis of H + ,K + ‐ATPase inhibitors.