The synthesis and chemistry of 5‐carboxy‐8‐mercaptoquinoline hydrochloride monohydrate: An intermediate in the synthesis of novel H + ,K + ‐ATPase inhibitors | Zendy

Zawistoski Michael P. | Zendy

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The synthesis and chemistry of 5‐carboxy‐8‐mercaptoquinoline hydrochloride monohydrate: An intermediate in the synthesis of novel H + ,K + ‐ATPase inhibitors

Author(s) -

Zawistoski Michael P.

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280321

Subject(s) - chemistry , yield (engineering) , pyrimidine , hydrochloride , sulfur , guanidine , chemical synthesis , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , materials science , metallurgy

The title compound 3 was prepared in six steps from 5‐nitro‐8‐hydroxyquinoline in 14% overall yield, using a substituted pyrimidine as a protecting group for sulfur. This offers a simple entry into the synthesis of 5‐carboxy‐8‐substituted thioquinolines, useful intermediates for the synthesis of H + ,K + ‐ATPase inhibitors.

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