The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate | Zendy

Kiely John S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate

Author(s) -

Kiely John S.

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280265

Subject(s) - chemistry , regioselectivity , medicinal chemistry , double bond , deprotonation , carboxylate , methylation , carboxylic acid , masking (illustration) , stereochemistry , organic chemistry , catalysis , ion , biochemistry , gene , art , visual arts

Ethyl 7‐Chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acid has been prepared by a route involving masking of the C 2,3 double bond through reduction, followed by regioselective deprotonation of the C 5 position and methylation and then regeneration of the C 2,3 double bond via selenation, oxidation, and syn‐elimination.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research