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The preparation of ethyl 7‐chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylate
Author(s) -
Kiely John S.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280265
Subject(s) - chemistry , regioselectivity , medicinal chemistry , double bond , deprotonation , carboxylate , methylation , carboxylic acid , masking (illustration) , stereochemistry , organic chemistry , catalysis , ion , biochemistry , gene , art , visual arts
Ethyl 7‐Chloro‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐5‐methyl‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acid has been prepared by a route involving masking of the C 2,3 double bond through reduction, followed by regioselective deprotonation of the C 5 position and methylation and then regeneration of the C 2,3 double bond via selenation, oxidation, and syn‐elimination.