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Polycyclic N ‐hetero compounds. XXXV . Syntheses and anti‐platelet aggregation activity of 5,6‐Dihydro‐4 H ‐benzo[3,4]cyclohept[1,2‐ e ]imidazo[1,2‐ c ]pyrimidines with an oxygen function at the 1‐position
Author(s) -
Sasaki Kenji,
Sekiya Yuhki,
Nagamatsu Tomohisa,
Ohtomo Hiromi,
Nakayama Taiji,
Hirota Takashi
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280258
Subject(s) - chemistry , stereochemistry , pyrimidine , platelet aggregation , platelet , immunology , biology
Various 6,7‐dihydro‐5 H ‐benzo[6,7]cyclohepta[1,2‐ d ][pyrimidines bearing amino acid group at the 4‐position of the skeleton were synthesized by the reaction of 4‐chloro‐6,7‐dihydro‐5 H ‐benzo[6,7]cyclohepta[1,2‐ d ]‐pyrimidine with some amino acid, which were cyclized to 5,6‐dihydro‐4 H ‐benzo[3,4]cyclohept[1,2‐ e ]imidazo‐[1,2‐ c ]pyrimidines, corresponding to B‐homo‐11,13,15‐triazasteroids. Their inhibitory activities against platelet aggregation induced by collagen were also investigated.