Heterocyclic variants of the 1,5‐benzodiazepine system.  VI . Derivatives of 2‐methylthio‐4‐( p ‐r‐phenyl)‐3 H ‐1,5‐benzodiazepines | Zendy

Cortés Eduardo | Zendy; Martínez Roberto | Zendy; Ugalde Martha | Zendy; Maldonado Napoleón | Zendy

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Heterocyclic variants of the 1,5‐benzodiazepine system. VI . Derivatives of 2‐methylthio‐4‐( p ‐r‐phenyl)‐3 H ‐1,5‐benzodiazepines

Author(s) -

Cortés Eduardo,

Martínez Roberto,

Ugalde Martha,

Maldonado Napoleón

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280230

Subject(s) - chemistry , sodium hydride , ethyl iodide , methyl iodide , benzodiazepine , hydride , medicinal chemistry , mass spectrometry , sodium iodide , iodide , stereochemistry , organic chemistry , chromatography , biochemistry , receptor , hydrogen

Ethyl 3‐[3 H ‐1,5‐benzodiazepin‐2‐yl]carbazates II were prepared in moderate yields from the title compounds and ethyl carbazate. The compounds II were easily transformed into 1 H‐s ‐triazolo[4,3‐a][1,5]benzodiazepin‐1‐ones III via a one‐step procedure. Reaction of triazolo‐1,5‐benzodiazepinones III with sodium hydride in methyl iodide gave a mixture of products from which were isolated two compounds IV and V . The structure of all products was confirmed by ir, 1 H nmr and mass spectrometry.

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