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Metallation of diazines. III . New synthesis of analogues of trimethoprim and of bacimethrin
Author(s) -
Ple N.,
Turck A.,
Fiquet E.,
Queguiner G.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280213
Subject(s) - chemistry , trimethoprim , derivative (finance) , lithium (medication) , iodine , chloride , medicinal chemistry , organic chemistry , antibiotics , medicine , biochemistry , financial economics , economics , endocrinology
Abstract 4‐Chloro‐2,6‐dimethoxypyrimidine was lithiated by lithium 2,2,6,6‐tetramethylpiperidide. The resulting lithio derivative was submitted to reaction with carbonyl derivatives, iodine and trimethyltin chloride. Synthesis of analogues of trimethoprim and of bacimetrin are reported.