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Novel 7‐substituted quinolone antibacterial agents. Synthesis of 7‐alkenyl, cycloalkenyl, and 1,2,3,6‐tetrahydro‐4‐pyridinyl‐1,8‐naphthyridines
Author(s) -
Laborde Edgardo,
Kiely John S.,
Lesheski Lawrence E.,
Schroeder Mel C.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280133
Subject(s) - chemistry , quinolone , combinatorial chemistry , medicinal chemistry , organic chemistry , antibiotics , biochemistry
A convergent synthesis of 1,8‐naphthyridine antibacterials bearing a carbon‐carbon bonded, acyclic or cyclic vinyl substituent at the C‐7 position has been achieved. The synthetic methodology is based upon the palladium‐catalyzed cross coupling of a 7‐chloro‐1,8‐naphthyridine with an appropriately substituted organotin reagent.