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Synthesis and identification of new thieno[3,2‐ b ] benzothiophenes
Author(s) -
Jackson Johnny L.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280119
Subject(s) - chemistry , thionyl chloride , regioselectivity , chloride , organic chemistry , medicinal chemistry , catalysis
The reaction of 2‐lithiobenzo[ b ]thiophenes with ketones produced 2‐hydroxyalkylbenzo[ b ]thiophenes which were cyclized in thionyl chloride to give novel thieno[3,2‐ b ][1]benzothiophenes. Oxidation with peroxyacetic acid gave the S,S ‐dioxides whose regiochemistry was identified from 1 H nmr model studies using substituted benzo[ b ]thiophenes and their corresponding‐1,1‐dioxides [1].