Premium
5‐Heteroaryl‐2‐thiophenecarboxylic acids: Oxazoles and oxadiazoles
Author(s) -
Goddard Carl J.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280104
Subject(s) - chemistry , oxazole , oxadiazole , alkyl , thiophene , aryl , carboxylic acid , cleavage (geology) , organic chemistry , lactam , combinatorial chemistry , geotechnical engineering , fracture (geology) , engineering
The synthesis of novel thiophene‐2‐carboxylic acids bearing alkyl and aryl‐substituted oxazole and oxadiazole rings is reported. Sequential functionalization of the key precursor, 5‐formyl‐2‐thiophenecarboxylic acid furnished the intermediate carboxylic acid esters which were converted into desired acids by basic cleavage.