Premium
The synthesis of substituted 2,3‐dihydrothieno[2,3‐ b ]‐thiophenes via intramolecular michael addition
Author(s) -
Williams Theresa M.,
Hudcosky Ronald J.,
Hunt Cecilia A.,
Shepard Kenneth L.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280103
Subject(s) - chemistry , intramolecular force , michael reaction , thiophene , ring (chemistry) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis
The first regiospecific synthesis of the 2,3‐dihydrothieno[2,3‐ b ]thiophene ring system was achieved using an intramolecular Michael addition in the key cyclization step. This strategy represents a novel and potentially general method for dihydrothiophene and dihydrothiophene S,S ‐dioxide annellation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom