Premium
The synthesis of ring‐expanded analogues of xanthine containing the imidazo[4,5‐ e ][1,4]diazepine ring system
Author(s) -
Hosmane Ramachandra S.,
Bhan Anila
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270759
Subject(s) - diazepine , chemistry , ring (chemistry) , stereochemistry , alkyl , combinatorial chemistry , xanthine , medicinal chemistry , organic chemistry , enzyme
The synthesis of 4,5,7,8‐tetrahydro‐6 H ‐imidazo[4,5‐ e ][1,4]diazepine‐5,8‐dione and its several 1‐ and 3‐alkyl (aralkyl) derivatives 2 has been reported. Mechanistic explorations of the final synthetic step as well as structural confirmation of a final product 2d by single‐crystal X‐ray diffraction analyses have also been presented.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom