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Phenylurethans of pyrazolidinols and piperidazinols as anticonvulsants
Author(s) -
Kornet Milton J.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270750
Subject(s) - chemistry , anticonvulsant , aryl , medicinal chemistry , organic chemistry , epilepsy , alkyl , neuroscience , biology
The synthesis of 1,2‐diethyl‐4‐hydroxymethylpyrazolidine ( II ) was accomplished in two steps from 1,2‐diethyl‐4‐ethoxycarbonylpyrazolidine ( I ). Also, 1,2‐dimethyl‐4‐hydroxypiperidazine ( VI ) was prepared in three steps from 1,2‐diethoxycarbonyl‐1,2,3,6‐tetrahydropyridazine ( IV ). The two alcohols were added to several aryl isocyanates and afforded fourteen new phenylurethan derivatives which showed moderate anticonvulsant activity in mice.