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Functionalized 5,6‐dihydro‐2 H ‐1,2,6‐thiadiazine 1,1‐dioxides. Synthesis, structure and chemistry
Author(s) -
Lee ChaiHo,
Kohn Harold
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270747
Subject(s) - chemistry , sulfamide , aryl , combinatorial chemistry , transformation (genetics) , generality , organic chemistry , stereochemistry , computational chemistry , psychology , biochemistry , alkyl , psychotherapist , gene
Treatment of sulfamide 4a and aryl‐substituted sulfamides 4b‐e with ethyl 3,3‐diethoxypropionate ( 13 ) provided a convenient procedure for the synthesis of functionalized 5,6‐dihydro‐2 H ‐1,2,6‐thiadiazine 1,1‐dioxides 14 . Key spectral properties of this novel class of heterocycles are reported. The generality and utility of this transformation is briefly explored.