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Synthesis of diastereomeric ketoconazole analogs
Author(s) -
Chapman David R.,
Bauer Ludwig,
Waller Donald P.,
Zaneveld Lourens J. D.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270739
Subject(s) - chemistry , diastereomer , ketoconazole , stereochemistry , nmr spectra database , organic chemistry , spectral line , antifungal , medicine , dermatology , physics , astronomy
Syntheses of trans ‐isomers of ketoconazole, and the corresponding des‐acetyl, 1‐methyl‐, 1‐formyl and 1‐methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis ‐diastereomers were characterized by their carbon‐13 nmr spectra.