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The synthesis of difluoro[1]benzothieno[2,3‐ c ]quinolines and their N ‐methyl quaternary salts
Author(s) -
Luo JiannKuan,
Castle Steven L.,
Castle Raymond N.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270737
Subject(s) - chemistry , medicinal chemistry , quaternary , stereochemistry , organic chemistry , paleontology , biology
A series of difluoro[1]benzothieno[2,3‐ c ]quinolines has been prepared by photocyclization of the appropriate carboxamides. The lactams obtained were converted into the corresponding chloro derivatives which were catalytically dechlorinated into the difluoro[1] benzothieno[2,3‐ c ]quinolines. The latter compounds were transformed into the N ‐methyl quaternary salts.