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A convenient synthesis of 1‐aryl‐3‐methyl‐1,2,4‐triazolin‐5‐ones from the reaction between acetone arylhydrazones and acetyl isocyanate
Author(s) -
Ray Partha S.,
Hank Richard F.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270732
Subject(s) - chemistry , acetone , isocyanate , aryl , hydrolysis , solvent , organic chemistry , alkyl , polyurethane
The reaction of acetone arylhydrazones with acetyl isocyanate gave the corresponding 4‐acetyl‐1‐aryl‐3,3‐dimethyl‐1,2,4‐triazolidin‐5‐ones which eliminated acetone upon acidic hydrolysis to give 1‐aryl‐3‐methyl‐1,2,‐4‐triazolin‐5‐ones. The above transformation can be achieved in one pot by a simple solvent swap.
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