Methylation of 2,4‐dihydro‐3 H ‐1,2,4‐triazol‐3‐ones. A structural determination of anhydro‐5‐aryl‐1,4‐dimethyl‐3‐hydroxy‐1,2,4‐triazolium hydroxides by two dimensional NMR | Zendy

Huber Edward W. | Zendy; Kane John M. | Zendy

Premium

Methylation of 2,4‐dihydro‐3 H ‐1,2,4‐triazol‐3‐ones. A structural determination of anhydro‐5‐aryl‐1,4‐dimethyl‐3‐hydroxy‐1,2,4‐triazolium hydroxides by two dimensional NMR

Author(s) -

Huber Edward W.,

Kane John M.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270720

Subject(s) - chemistry , methyl iodide , yield (engineering) , alkylation , hydroxide , methylation , medicinal chemistry , iodide , aryl , organic chemistry , stereochemistry , catalysis , alkyl , materials science , metallurgy , biochemistry , gene

The syntheses of 5‐[3‐( n ‐butoxy)‐4‐methoxyphenyl]‐4‐methyl‐2,4‐dihydro‐3 H ‐1,2,4‐triazol‐3‐one ( 6 ) and 5‐[3‐( n ‐butoxy)‐4‐methoxyphenyl]‐2,4‐dimethyl‐2,4‐dihydro‐3 H ‐1,2,4‐triazol‐3‐one ( 7 ) are reported. The alkylation of 6 with methyl iodide to yield 7 also yields anhydro‐5‐[3‐( n ‐butoxy)‐4‐methoxyphenyl]‐1,4‐dimethyl‐3‐hydroxy‐1,2,4‐triazolium hydroxide ( 8 ). The structures of these products are substantiated using 2D nmr techniques.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research