Synthesis of 5‐substituted pyrimidines.  ortho ‐directed lithiation of pyrimidine derivatives | Zendy

Wada Akimori | Zendy; Yamamoto Junpei | Zendy; Hamaoka Yuka | Zendy; Ohki Kazuhiro | Zendy; Nagai Sotoo | Zendy; Kanatomo Shōichi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 5‐substituted pyrimidines. ortho ‐directed lithiation of pyrimidine derivatives

Author(s) -

Wada Akimori,

Yamamoto Junpei,

Hamaoka Yuka,

Ohki Kazuhiro,

Nagai Sotoo,

Kanatomo Shōichi

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270658

Subject(s) - chemistry , electrophile , pyrimidine , lithium (medication) , ether , alkoxy group , medicinal chemistry , quenching (fluorescence) , organic chemistry , stereochemistry , alkyl , catalysis , medicine , physics , quantum mechanics , fluorescence , endocrinology

ortho ‐Directed lithiation of some pyrimidines has been investigated. Treatment of 2‐ and/or 4‐alkoxy or acylaminopyrimidine with lithium 2,2,6,6‐tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5‐substituted pyrimidines.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research