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Synthesis of 5‐substituted pyrimidines. ortho ‐directed lithiation of pyrimidine derivatives
Author(s) -
Wada Akimori,
Yamamoto Junpei,
Hamaoka Yuka,
Ohki Kazuhiro,
Nagai Sotoo,
Kanatomo Shōichi
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270658
Subject(s) - chemistry , electrophile , pyrimidine , lithium (medication) , ether , alkoxy group , medicinal chemistry , quenching (fluorescence) , organic chemistry , stereochemistry , alkyl , catalysis , medicine , physics , quantum mechanics , fluorescence , endocrinology
ortho ‐Directed lithiation of some pyrimidines has been investigated. Treatment of 2‐ and/or 4‐alkoxy or acylaminopyrimidine with lithium 2,2,6,6‐tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5‐substituted pyrimidines.