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Heterocyclic system. XI . Synthesis of 1 H ,4 H ‐pyrazolo[4,3‐ b ]pyrrolizine and 2 H ,4 H ‐pyrazolo[4,3‐ b ]pyrrolizine derivatives
Author(s) -
Massa Silvio,
Mai Antonello,
Artico Marino,
Corelli Federico
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270653
Subject(s) - chemistry , pyrazole , carboxylic acid , stereochemistry , medicinal chemistry , organic chemistry
Cyclization of pyrrolidinocarboxamide derivatives of 1‐phenyl‐5‐(1 H ‐pyrrol‐1‐yl)‐1 H ‐pyrazole‐4‐carboxylic acid and 2‐phenyl‐3‐(1 H ‐pyrrol‐1‐yl)‐1 H ‐pyrazole‐4‐carboxylic acid afforded imminium salts which were transformed into the corresponding ketones. Further reduction of the latter compounds furnished the title derivatives.