Premium
N ‐chlorination of dilantin and sorbinil
Author(s) -
Lipinski Christopher A.,
Bordner Jon,
Butterfield Garth C.,
Marinovic Lilian C.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270651
Subject(s) - chemistry , sorbinil , aldose reductase inhibitor , aldose reductase , anticonvulsant , drug , stereochemistry , medicinal chemistry , organic chemistry , pharmacology , enzyme , epilepsy , medicine , neuroscience , biology
The synthesis, stability, X‐ray structural characterization and 13 C nmr shifts of N ‐1′, N ‐3′‐dichloro and N ‐1′‐monochlorohydantoin derivatives of the anticonvulsant dilantin and the aldose reductase inhibitor sorbinil are described. These chlorinated derivatives may be involved in drug induced hypersensitivity reactions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom