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N ‐chlorination of dilantin and sorbinil
Author(s) -
Lipinski Christopher A.,
Bordner Jon,
Butterfield Garth C.,
Marinovic Lilian C.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270651
Subject(s) - chemistry , sorbinil , aldose reductase inhibitor , aldose reductase , anticonvulsant , drug , stereochemistry , medicinal chemistry , organic chemistry , pharmacology , enzyme , epilepsy , medicine , neuroscience , biology
The synthesis, stability, X‐ray structural characterization and 13 C nmr shifts of N ‐1′, N ‐3′‐dichloro and N ‐1′‐monochlorohydantoin derivatives of the anticonvulsant dilantin and the aldose reductase inhibitor sorbinil are described. These chlorinated derivatives may be involved in drug induced hypersensitivity reactions.