Thiophene systems.  11 . The synthesis of novel thieno[4,3,2‐ de ] tricyclic ring systems | Zendy

Russell Ronald K. | Zendy; Rampulla Richard A. | Zendy; van Nievelt Caroline E. | Zendy; Klaubert Dieter H. | Zendy

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Thiophene systems. 11 . The synthesis of novel thieno[4,3,2‐ de ] tricyclic ring systems

Author(s) -

Russell Ronald K.,

Rampulla Richard A.,

van Nievelt Caroline E.,

Klaubert Dieter H.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270647

Subject(s) - chemistry , tricyclic , methanesulfonic acid , ring (chemistry) , alkylation , thiophene , phosphorus pentoxide , hydrolysis , organic chemistry , medicinal chemistry , stereochemistry , catalysis

The synthesis of thieno[4,3,2‐ de ] tricyclic compounds is described. The N ‐1 alkylation of I produced the alkanoic ester precursors. After hydrolysis, the corresponding carboxylic acids were cyclized to the title compounds II . This cyclization step was accomplished with 1:10 phosphorus pentoxide‐methanesulfonic acid. The ketones II were further modified to introduce additional functionality onto this novel tricyclic ring system.

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