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Generation and dienophilic properties of 1‐benzyl‐1 H ‐1,2,3‐triazolo[4,5‐ d ]pyridazine‐4,7‐dione
Author(s) -
Theocharis A. B.,
Alexandrou N. E.,
Terzis A.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270643
Subject(s) - pyridazine , chemistry , adduct , stereochemistry , medicinal chemistry , organic chemistry
1‐Benzyl‐5,6‐dihydro‐1 H ,2,3‐triazolo[4,5‐ d ]pyridazine‐4,7‐dione ( 1 ) by oxidation with lead tetraacetate afforded the corresponding triazolopyridazine‐4,7‐dione 2 as the intermediate, which was trapped with several dienes giving the hetero‐Diels‐Alder adducts 3 in good yields. The structure of the cycloadduct 3a was determined by X‐ray analysis.