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Synthesis of 5‐benzyl and 5‐benzyloxybenzyl‐3′‐azido‐2′,3′‐dideoxyuridine and their analogues as potential anti‐AIDS agents
Author(s) -
Pan BaiChuan,
Weng ZumYao,
Chen ZhiHao,
Rowe Elizabeth C.,
Chu ShihHsi
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270609
Subject(s) - chemistry , epimer , stereochemistry , uracil , biochemistry , dna
5‐Benzyl and 5‐benzyloxybenzyl‐substituted 3′‐azido‐2′,3′‐dideoxyuridine, ( 8a and 8b ), 3′‐halogeno‐2′,3′‐dideoxyuridine, 9a, 9b, 10a, 10b, 11a and 11b , and 2′,3′‐dideoxyuridine, 12a and 12b , of Scheme I were synthesized as potential anti AIDS agents. Synthesis of epimers of 8a and 8b , 5‐benzyl‐ and 5‐benzyloxybenzyl‐1‐(3′‐azido‐2′,3′‐dideoxy‐β‐D‐threo‐pentafuranosyl)uracil, 15a and 15b , and 5‐benzyl‐ and 5‐benzyloxy‐5′‐azido‐2′,5′‐dideoxyuridine, 16a and 16b , shown in Scheme II, were also reported.
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