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Proton‐ionizable crown compounds. 19 . The synthesis of chiral dialkyl‐substituted triazolo‐18‐crown‐6 macrocycles
Author(s) -
Bradshaw Jerald S.,
Mcdaniel Christopher W.,
Krakowiak Krzysztof E.,
Izatt Reed M.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270554
Subject(s) - chemistry , isopropyl , ring (chemistry) , triazole , 18 crown 6 , proton , crown (dentistry) , asymmetric carbon , substituent , cyclophane , stereochemistry , medicinal chemistry , organic chemistry , crystal structure , molecule , optically active , medicine , physics , dentistry , quantum mechanics
Four new chiral macrocyclic polyether ligands containing the proton‐ionizable triazole subcyclic unit have been prepared. The triazolo‐crowns contain two isopropyl, two isobutyl, two ( S )‐ sec ‐butyl or two benzyl substituents on chiral macro ring carbon atoms. A racemic triazolo‐18‐crown‐6 containing two (1‐naphthoxy)methyl substituents was also prepared.
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