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Metallation of diazines II . First metallation of pyridazine, metallation of 2,4‐dichloropyrimidine
Author(s) -
Turck A.,
Plé N.,
Mojovic L.,
Quéguiner G.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270536
Subject(s) - chemistry , pyridazine , regioselectivity , metalation , lithium (medication) , medicinal chemistry , organic chemistry , catalysis , medicine , endocrinology
3,6‐Dichloropyridazine was ortho‐lithiated by lithium 2,2,6,6‐tetramethylpiperidide. The resulting lithio compound was reacted with carbonyl derivatives iodine and trimethylchlorosilane. An azaxanthone was synthesised. An unusual regioselectivity for the lithiation of 2,4‐dichloropyrimidine was studied.