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Synthesis of isochroman‐fused pyrazolone and pyrimidine derivatives
Author(s) -
Wang JinJun,
Yin BingZhu,
Jiang GuiJi,
Imafuku Kimiaki
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270504
Subject(s) - chemistry , pyrazolone , hydrazine (antidepressant) , pyrimidine , aryl , pyrazolones , medicinal chemistry , organic chemistry , stereochemistry , alkyl , chromatography
Unsubstituted 5 , and 2‐aryl‐ 6a‐c , or 2‐(2‐benzothiazolyl)‐substituted 1,3‐dihydroisochromano[4,3‐ c ]pyrazol‐3(2 H )‐ones 7a‐f were prepared by the reactions of 3‐ethoxyoxalyl‐ 2 , or 3‐ethoxycarbonylisochroman‐4‐one 3 with hydrazine derivatives. The reactions with amidines gave 2‐substituted 4‐hydroxyisochromano[4,3‐ d ]‐pyrimidines 8a‐c .
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