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Potential antitumor agents. IV. Pyrrole analogues of oncodazole
Author(s) -
Massa Silvio,
Santo Roberto Di,
Artico Marino
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270461
Subject(s) - chemistry , pyrrole , alkyl , antifungal , anthelmintic , derivative (finance) , stereochemistry , combinatorial chemistry , organic chemistry , microbiology and biotechnology , ecology , financial economics , economics , biology
The synthesis of alkyl [5‐(1 H ‐pyrrol‐2‐ylcarbonyl)‐1 H ‐benzimidazol‐2‐yl]carbamates and alkyl [5‐(1 H ‐pyrrol‐ 1‐ylmethyl)‐1 H ‐benzimidazol‐2‐yl]carbamates is described. The new pyrrole derivatives are related to oncodazole, a recent synthetic derivative showing antifungal, antitumor and anthelmintic properties.