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Pteridines bearing acetylene‐containing sidechains at c‐2:Preparation and attempted cycloaddition reactions
Author(s) -
Haider Norbert,
Van Der Plas Henk C.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270452
Subject(s) - chemistry , cycloaddition , acetylene , intramolecular force , pteridine , medicinal chemistry , organic chemistry , bearing (navigation) , photochemistry , stereochemistry , catalysis , enzyme , cartography , geography
The preparation of a series of pteridine derivatives 1a‐d bearing S‐, O‐, or C‐linked ω‐alkynyl side chains at C‐2 is described. Furthermore, an improved synthesis of 2‐chloropteridine is proposed. Compounds 1a‐d were found not to undergo intramolecular cycloaddition reactions under thermolytic conditions.

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