Synthesis of 17β‐hydroxy‐1′‐ H ‐5α‐androst‐2‐eno[3,2‐ b ]pyrrole and 17β‐hydroxy‐1′‐ H ‐5α‐androst‐3‐eno[3,4‐ b ]pyrrole from  O ‐(2‐hydroxyethyl)ketoxime precursors | Zendy

Ellames George J. | Zendy; Johnston David | Zendy; Smith David I. | Zendy

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Synthesis of 17β‐hydroxy‐1′‐ H ‐5α‐androst‐2‐eno[3,2‐ b ]pyrrole and 17β‐hydroxy‐1′‐ H ‐5α‐androst‐3‐eno[3,4‐ b ]pyrrole from O ‐(2‐hydroxyethyl)ketoxime precursors

Author(s) -

Ellames George J.,

Johnston David,

Smith David I.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270451

Subject(s) - chemistry , pyrrole , medicinal chemistry , stereochemistry , organic chemistry

Pyrrolosteroids such as 17β‐hydroxy‐1′‐ H ‐5α‐androst‐2‐eno[3,2‐ b ]pyrrole ( 1 ) and the novel 17β‐hydroxy‐1′‐ H ‐5α‐androst‐3‐eno[3,4‐ b ]pyrrole ( 12 ) can be synthesized from the corresponding O ‐(2‐hydroxyethyl)ketoxime precursors. In the case of 1 , yields compare favourably with previously reported literature methods.

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