Premium
Synthesis of 17β‐hydroxy‐1′‐ H ‐5α‐androst‐2‐eno[3,2‐ b ]pyrrole and 17β‐hydroxy‐1′‐ H ‐5α‐androst‐3‐eno[3,4‐ b ]pyrrole from O ‐(2‐hydroxyethyl)ketoxime precursors
Author(s) -
Ellames George J.,
Johnston David,
Smith David I.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270451
Subject(s) - chemistry , pyrrole , medicinal chemistry , stereochemistry , organic chemistry
Pyrrolosteroids such as 17β‐hydroxy‐1′‐ H ‐5α‐androst‐2‐eno[3,2‐ b ]pyrrole ( 1 ) and the novel 17β‐hydroxy‐1′‐ H ‐5α‐androst‐3‐eno[3,4‐ b ]pyrrole ( 12 ) can be synthesized from the corresponding O ‐(2‐hydroxyethyl)ketoxime precursors. In the case of 1 , yields compare favourably with previously reported literature methods.