Synthesis and chemical reactivity of c‐5 substituted 6,7‐bis‐(hydroxymethyl)‐1 H ‐pyrrolizine biscarbamate tumor inhibitors | Zendy

Anderson Wayne K. | Zendy; Mach Robert H. | Zendy

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Synthesis and chemical reactivity of c‐5 substituted 6,7‐bis‐(hydroxymethyl)‐1 H ‐pyrrolizine biscarbamate tumor inhibitors

Author(s) -

Anderson Wayne K.,

Mach Robert H.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270440

Subject(s) - chemistry , reactivity (psychology) , hydroxymethyl , pyridine , nucleophile , alkylation , stereochemistry , chemical synthesis , in vitro , medicinal chemistry , organic chemistry , biochemistry , catalysis , medicine , alternative medicine , pathology

A series of C‐5 substituted pyrrolizine biscarbamate alkylating agents were synthesized and evaluated in an in vitro alkylation assay. Introduction of electron‐withdrawing substituents at the C‐5 position resulted in a dramatic decrease in chemical reactivity toward the model nucleophile 4‐(4‐nitrobenzyl)pyridine (NBP).

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