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One‐step methods to prepare cryptands and crowns containing reactive functional groups
Author(s) -
Krakowiak Krzysztof E.,
Bradshaw Jerald S.,
Izatt Reed M.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270437
Subject(s) - chemistry , cryptand , yield (engineering) , triethanolamine , alkene , aziridine , medicinal chemistry , organic chemistry , ring (chemistry) , catalysis , analytical chemistry (journal) , ion , materials science , metallurgy
A one‐step synthesis of cryptand [2.2.2] containing three methylenyl substituents in a 25% yield from the reaction of triethanolamine and 3‐chloro‐2‐chloromethyl‐1‐propene is described. A similar cryptand was prepared in 56% yield by a two‐step process. One‐step syntheses of N,N ‐hydroxyethyl‐diaza‐18‐crown‐6 and crown‐6 compounds containing two alkene functional groups are also described.