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The synthesis of benzofuroquinolines. VIII. Some halobenzofuro[2,3‐ c ]quinoline derivatives
Author(s) -
Yamaguchi Seiji,
Yokoi Takashi,
Yamada Minoru,
Arai Hitomi,
Uchiuzo Yasuto,
Kawase Yoshiyuki
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270435
Subject(s) - chemistry , quinoline , condensation , halo , medicinal chemistry , stereochemistry , organic chemistry , physics , quantum mechanics , galaxy , thermodynamics
Three 2‐halo‐6(5 H )‐benzofuro[2,3‐ c ]quinolinones 1 (X = F, Cl, Br) were synthesized in two procedures, photocyclization of N ‐benzyl‐ N ‐( p ‐halophenyl)‐2‐benzofurancarboxamides 3 (X = F, Cl, Br) and condensation of 2‐amino‐2′‐hydroxybenzophenones 7 (X = F, Cl, Br) with chloroacetonitrile. Three 2‐halo‐6‐methylbenzofuro[2,3‐ c ]quinolines 2 (X = F, Cl, Br) were also synthesized by the condensation of 2‐amino‐5‐halo‐2′‐hydroxybenzophenones 7 (X = F, Cl, Br) with chloroacetone.