Novel syntheses of dihydroxanthyletin and dihydroseselin derivatives | Zendy

Jetter Michele M. | Zendy; Heindel Ned D. | Zendy; Laskin Jeffrey D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Novel syntheses of dihydroxanthyletin and dihydroseselin derivatives

Author(s) -

Jetter Michele M.,

Heindel Ned D.,

Laskin Jeffrey D.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270433

Subject(s) - chemistry , ring (chemistry) , alkylation , coumarin , halide , closure (psychology) , carbon fibers , medicinal chemistry , stereochemistry , organic chemistry , catalysis , materials science , composite number , economics , market economy , composite material

In a one‐step alkylation, ring‐closure 7‐hydroxycoumarins are condensed in acid media with allyl and homoallyl halides or alcohols to linear 6,7‐dihydro‐2 H ,8 H‐ benzo[1,2–6:5,4‐ b' ]dipyran‐2‐ones. If both carbon‐6 and carbon‐8 are unsubstituted in the original coumarin, cyclization to angular isomers 9,10‐dihydro‐2 H ,8 H ‐benzo[1,2–6:3,4‐ b' ]dipyran‐2‐ones competes. These compounds are higher ring homologs of psoralens and angelicins commonly employed in phototherapy of skin disorders.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research