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Saturated heterocycles, part 161 [1]. Synthesis of 2‐hydroxycycloalkyl‐substituted 1,3,4‐oxadiazoles, 1,3,4‐thiadiazoles and 1,2,4‐triazoles
Author(s) -
Fülöp Ferenc,
Semega éva,
Dombi György,
Bernáth Gábor
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270424
Subject(s) - chemistry , thiadiazoles , oxadiazole , ring (chemistry) , isothiocyanate , phenyl isothiocyanate , triazole , isocyanate , adduct , phenyl isocyanate , medicinal chemistry , stereochemistry , organic chemistry , polyurethane
A number of 2‐hydroxycycloalkyl‐substituted 1,3,4‐oxadiazole, 1,3,4‐thiadiazole and 1,2,4‐triazole derivatives were prepared by different methods from cis‐ and trans ‐2‐hydroxy‐1‐cycloalkanecarbohydrazides and their isocyanate or isothiocyanate adducts. In contrast with the related ring‐closure reactions of 2‐aminobenzoylhydrazides, no condensed skeleton heterocycles were formed in this case.