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Regioselective synthesis of trifluoromethylated pyrazoles by selective protection of trifluoromethyl‐β‐diketones
Author(s) -
Lyga John W.,
Patera Russell M.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270418
Subject(s) - chemistry , regioselectivity , pyrrolidine , trifluoromethyl , quenching (fluorescence) , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , alkyl , physics , quantum mechanics , fluorescence
1,1,1‐Trifluoropentane‐2,4‐dione was selectively protected by treatment with pyrrolidine to give 6 . The reaction of 6 with arylhydrazines gave 5 exclusively. The structural assignment for 5 was confirmed by quenching the dianion of 8 with ethyl trifluoroacetate.