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One step synthesis of pyrimido[1,2‐ a ][1,8]naphthyridinones, pyrido[1,2‐a]pyrimidinones and 1,8‐naphthyridinones. Antihypertensive agents. V
Author(s) -
Ferrarini Pier Luigi,
Mori Claudio,
Primofiore Giampaolo,
Calzolari Lorella
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270411
Subject(s) - pyrimidinones , chemistry , 2 aminopyridine , condensation , stereochemistry , medicinal chemistry , combinatorial chemistry , physics , thermodynamics
The condensation of 2,6‐diaminopyridine and 2‐acetamido‐6‐aminopyridine with β‐keto esters in polyphosphophoric acid was studied. In this reaction some 1,8‐naphthyridinones, pyrido[1,2‐ a ]pyrimidinones and pyrimido[1,2‐ a ][1,8]naphthyridinones variously substituted were obtained.