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A facile synthesis of novel 1,2‐diazepino[3,4‐ b ]quinoxalines by a 1,3‐dipolar cycloaddition reaction
Author(s) -
Kim Ho Sik,
Kurasawa Yoshihisa,
Yoshii Chiemi,
Masuyama Minako,
Takada Atsushi,
Okamoto Yoshihisa
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270364
Subject(s) - chemistry , quinoxaline , cycloaddition , 1,3 dipolar cycloaddition , medicinal chemistry , stereochemistry , organic chemistry , catalysis
The 1,3‐dipolar cycloaddition reaction of the quinoxaline 4‐oxides 4a,b with 2‐chloroacrylonitrile gave the 2,3‐dihydro‐1 H ‐1,2‐diazepino[3,4‐ b ]quinoxalines 5a,b , respectively, which were converted into the 2,3,4,6‐tetrahydro‐1 H ‐1,2‐diazepino[3,4‐ b ]quinoxalines 7a,b and 8a,b , respectively.