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Synthesis of fluoromethyl, difluoromethyl and trifluoromethyl analogues of pyrazosulfuron‐ethyl as herbicides
Author(s) -
Morimoto Katsushi,
Makino Kenzi,
Yamamoto Susumu,
Sakata Gozyo
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270360
Subject(s) - chemistry , trifluoromethyl , carboxylate , difluorocarbene , pyrazole , medicinal chemistry , organic chemistry , alkyl
Ethyl 1‐fluoromethyl‐5‐(4,6‐dimethoxypyrimidin‐2‐ylcarbamoylsulfamoyl)pyrazole‐4‐carboxylate 1b , a new fluoromethyl analogue of the herbicide pyrazosulfuron‐ethyl la, was prepared from ethyl 1‐fluoromethylpyrazole‐4‐carboxylate 4b . The difluoromethyl and trifluoromethyl analogues 1c,d were also synthesized from ethyl pyrazole‐4‐carboxylate 2 via difluorocarbene reaction.