Synthesis of substituted dihydrobenzo[ f ]pyrimido[4,5‐ b ]‐quinolines as tetracyclic 5‐deaza nonclassical folates | Zendy

Donkor Isaac O. | Zendy; Gangjee Aleem | Zendy; Duah Francis K. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of substituted dihydrobenzo[ f ]pyrimido[4,5‐ b ]‐quinolines as tetracyclic 5‐deaza nonclassical folates

Author(s) -

Donkor Isaac O.,

Gangjee Aleem,

Duah Francis K.

Publication year - 1990

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570270353

Subject(s) - chemistry , quinoline , structural isomer , aldehyde , stereochemistry , organic chemistry , catalysis

Cyclocondensation of 2,4,6‐triaminopyrimidine ( 10 ) with chlorovinyl aldehyde 7 afforded the linear regioisomer 9,1 1‐diamino‐5,6‐dihydrobenzo[ f ]pyrimido[4,5‐ c ]quinoline ( 1 ) while the cyclocondensation of 2,6‐diamino‐4‐hydroxypyrimidine ( 11 ) or 6‐amino‐2,4‐dihydroxypyrimidine ( 12 ) with chlorovinyl aldehyde 7 was regiospecific affording the linear regioisomers 9‐amino‐11‐oxo‐5,6‐dihydrobenzo[ f ]pyrimido[4,5‐ c ]quinoline ( 2 ) and 9,11‐dioxo‐5,6‐dihydrobenzo[ f ]pyrimido[4,5‐ c ]quinoline ( 3 ) respectively. The linear structures of these compounds were established by 1 H nmr and 13 C nmr spectral data.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research