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Synthesis of 1‐aryl‐1,2,3‐triazole‐4,5‐dimethanol‐4,5‐bis(isopropylcarbamates) as potential antineoplastic agents
Author(s) -
Lalezari I.,
Gomez L. A.,
Khorshidi M.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270338
Subject(s) - chemistry , aryl , triazole , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , alkyl
Starting with aryl azides, 1‐aryl‐1,2,3‐triazole‐4,5‐dimethanol‐4,5‐bis(isopropylcarbamates), a new class of potential antineoplastic agents, were synthesized. In vitro antileukemic and antitumor actmües of the compounds synthesized were also evaluated.