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Synthesis and reactions of 3‐thioxo[1,2,4]‐triazino[3,2‐ b ]quinazolin‐10‐ones
Author(s) -
Eid Mohga M.,
ElZanaty Ali,
Ibrahim Yehia A.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270322
Subject(s) - chemistry , hydrazine (antidepressant) , aniline , ring (chemistry) , quinazoline , derivative (finance) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , chromatography , financial economics , economics
Abstract Thiation of [1,2,4]triazino[3,2‐ b ]quinazoline‐3,10‐dione 1 proceeds selectively to give the 3‐thioxo‐analog 3 . The latter was converted to the corresponding 3‐methylthio derivative 4 which was reacted with aniline and hydrazine to give the corresponding anilino‐ and hydrazino derivatives 5 and 7 . Compound 7 was converted to the hydrazones 8a,b and into the novel heterocyclic ring systems [1,2,4]triazolo[4′,3′:4,5][1,2,4]triazino‐[3,2‐ b ]quinazolin‐7‐ones 9, 10a,b and tetrazolo[1′,5′:4,5][1,2,4]triazino[3,2‐ b ]quinazolin‐7‐one 11 .