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The synthesis and biological activity of 8‐fluoro‐9‐(4‐methyl‐1‐piperazinyl)‐6‐oxo‐6 H ‐benzo[ c ]quinolizine‐5‐carboxylic acid
Author(s) -
Ziegler Carl B.,
Moran Daniel B.,
Fenton Thomas J.,
Lin YangI.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270321
Subject(s) - chemistry , intramolecular force , nucleophilic substitution , ring (chemistry) , chloride , condensation , stereochemistry , biological activity , nucleophile , medicinal chemistry , carboxylate , organic chemistry , in vitro , catalysis , biochemistry , thermodynamics , physics
A one‐pot synthesis of ethyl 8,9‐difluoro‐6‐oxo‐6 H ‐benzo[ c ]quinolizine‐5‐carboxylate 11 has been developed. The condensation of ethyl 2‐pyridylacetate and 2,4,5‐trifluorobenzoyl chloride followed by intramolecular nucleophilic aromatic substitution gave the desired ring system. This intermediate was converted to the title compound and its in vitro biological activity is reported.