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A novel preparation of thiazolo[5,4‐ c ]pyridines and the synthesis of some imidazo[4,5‐ c ]pyridines and oxazolo[4,5‐ c ]pyridines
Author(s) -
Katner Allen S.,
Brown Raymond F.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270316
Subject(s) - chemistry , imidazole , aminopyridines , pyridine , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Diethoxymethyl acetate was used to cyclize o ‐disubstituted aminopyridines to oxazolo[4,5‐ c ]pyridines and imidazo[4,5‐ c ]pyridines. All the possible imidazole‐methylated imidazo[4,5‐ c ]pyridines were prepared. A novel synthesis of 2‐substituted thiazolo[5,4‐ c ]pyridines and 4‐amino‐3‐pyridinethiol was discovered.