Premium
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2 H )‐pyridazinones
Author(s) -
Baraldi P. G.,
Chiarini A.,
Leoni A.,
Manfredini S.,
Simoni D.,
Zanirato V.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270315
Subject(s) - chemistry , cleavage (geology) , bond cleavage , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , geotechnical engineering , fracture (geology) , engineering
A convenient synthetic method for the pharmaceutically important 6‐substituted‐4,5‐dihydro‐3(2 H )‐pyridazinones is described. The synthetic strategy is based on Δ‐soxazolines chemistry which were in turn unmasked by NO bond cleavage and cyclized to the target compounds.