Premium
Synthesis of 4‐[3‐(1 H )‐indolyl]‐2‐[ N ‐guanidinomethyl]thiazole dihydrochloride
Author(s) -
Zawistoski Michael P.
Publication year - 1990
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570270308
Subject(s) - chemistry , thiazole , pharmacophore , yield (engineering) , stereochemistry , combinatorial chemistry , metallurgy , materials science
The title compound 3b was synthesized in three steps from acetaminothioacetamide ( 4b ) in 15% overall yield. This represents the first synthesis of a 2‐guanidinomethylthiazole, which is a homolog of an important pharmacophore, 2‐guanidinothiazole.